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Filtered Search Results
BIOHIPPO AnRE-TAL-Puro LV
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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AnRE-TAL-Puro is a transcription factor reporter lentiviral vector designed to monitor Androgen receptor (AR) signaling pathway in living cells This construct delivers a Firefly Luc reporter cassette together with a Puromycin selection marker for generation of stable cell pools The vector is provided as a ready to use Lentivirus preparation pseudotyped with VSV-G for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 2x10E6 transducing units TU Typical applications include Monitor AR signaling pathway activity in mammalian cells screen for activators or inhibitors of the AR signaling pathway The fluorescent reporter enables convenient readout using flow cytometry fluorescence microscopy etc The system is suitable for use with Human/mouse and can support assay development high content screening and mechanism of action studies This product is intended for research use only and is not for diagnostic or therapeutic procedures
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Picalm protein, human (HEK293, His) | >95.0% | 50UG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Recombinant human PICALM protein produced in HEK293 cells with a C-terminal His tag, supplied as a 50 μg vial for research use. The protein is >95% pure by reducing SDS-PAGE and has an approximate molecular weight of 90-150 kDa. Store long-term at -80°C and avoid repeated freeze-thaw cycles. Intended applications include biochemical assays, antibody production, and protein-protein interaction studies.
- High purity suitable for sensitive assays.
- HEK293 expression ensures mammalian post-translational modifications.
- C-terminal His tag enables straightforward purification and detection.
- Supplied in small aliquots to minimize freeze-thaw damage.
- Includes supporting documents (SDS, COA, data sheet) for quality verification.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC N-Methyliminodiacetic acid-d4 | 1219803-27-6 | 156.17 | 5 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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2,2'-(Methylazanediyl)diacetic acid-d4 is a deuterium-labeled compound. Deuterium substitution in drug molecules is explored for its potential to influence pharmacokinetic and metabolic profiles.
- Deuterium-labeled compound
- Used as a tracer for quantitation in drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
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Medchemexpress LLC Imidazo[1,2-a]pyridine-6-carboxamide, 2-(4-cyanophenyl)-N,N-bis(3-methylbutyl)-3-[3-(1-pyrrolidinyl)propyl]-, hydrochloride (1:1) | 1064662-40-3 | 99.5% | 550.18 | 25 MG
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SNT-207707 is a selective, potent, and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. It can cross the blood-brain barrier. It is for research use only.
- Selective, potent, and orally active melanocortin MC-4 receptor antagonist
- Binds to the MC-4 receptor with an affinity of 8 nM
- Shows more than 200-fold selectivity versus MC-3 and MC-5
- Can cross the blood-brain barrier
- Increases food intake in mice
- Reduces tumor-induced weight loss
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Medchemexpress LLC Squalamine lactate | 320725-47-1 | 98.4% | 718.04 | 1 MG
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Squalamine lactate | 320725-47-1 | 98.4% | 718.04 | 1 MG
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Medchemexpress LLC Sortilin antagonist 1 | 2691846-93-0 | 99.6% | 356.42 | 25 MG
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Sortilin antagonist 1 (compound 44) is a sortilin antagonist with an IC50 value of 20 nM for inhibiting Neurotensin (NTS) binding to sortilin. Neurotensin is a sortilin ligand. Sortilin antagonist 1 can be used for the research of neurological diseases.
- Sortilin antagonist with an IC50 value of 20 nM for inhibiting Neurotensin (NTS) binding to sortilin
- Neurotensin is a sortilin ligand
- Can be used for the research of neurological diseases.
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Medchemexpress LLC BAL-0028 | 2842012-69-3 | 99.9% | 403.45 | 25 MG
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BAL-0028 is a reversible inhibitor of NLRP3 activation. It binds closely to the NACHT domain of the NLRP3, inhibiting the secretion of IL-1β, and demonstrating anti-inflammatory activity.
- Reversible inhibitor of NLRP3 activation
- Binds to the NACHT domain of NLRP3
- Inhibits secretion of IL-1β
- Has anti-inflammatory activity
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Medchemexpress LLC MC4033 KAT8 inhibitor | 28532-21-0 | 98.3% | 295.29 | 1 MG
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MC4033 is a compound that shows inhibitory activity against KAT8 (lysine acetyltransferase 8) with an IC50 of 12.1 μM. It has demonstrated antiproliferative effects in various human cancer cell lines, including HCT116, H1299, A549, and U937, with IC50 values ranging from 30.1 μM to 52.1 μM. Additionally, MC4033 has been shown to reduce the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells.
- KAT8 inhibitor.
- Antiproliferative effects in several cancer cell lines.
- Induces apoptosis.
- Reduces oncogene mRNA levels.
- Activates autophagy.
- Synergistic apoptotic effect.
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Medchemexpress LLC Palovarotene | 410528-02-8 | 99.5% | 414.54 | 25 MG
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Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist, intended strictly for research use. It presents as an off-white to yellow solid.
- Acts as a nuclear retinoic acid receptor γ (RAR-γ) agonist.
- Suppresses post-traumatic chondrogenesis and osteogenesis, mitigating trauma-induced ectopic bone formation.
- Significantly decreases heterotopic ossification (HO) in mice by 50 to 60%.
- Being investigated in clinical trials for conditions such as Fibrodysplasia Ossificans Progressiva (FOP) and Dry Eye Disease.
- Has a high purity of 99.49%.
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Medchemexpress LLC Rivastigmine (Standard) | 123441-03-2 | 99.9% | 250.34 | 50 MG
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Rivastigmine (Standard) is the analytical standard of Rivastigmine, intended for research and analytical applications. It is an orally active and potent cholinesterase (ChE) inhibitor. This compound is an analytical standard used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Orally active and potent cholinesterase (ChE) inhibitor
- Inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)
- Can pass the blood-brain barrier (BBB)
- Used for research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease
- Analytical standard for HPLC, GC, and MS research experiments
- Appearance: Liquid, colorless to light yellow
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Medchemexpress LLC Liquiritin apioside | 74639-14-8 | 550.51 | 25 MG
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Liquiritin apioside is an orally active inhibitor of the TRPV1 receptor. It selectively inhibits laryngeal chemoreflex (LCR) without significantly affecting mechanoreflex (LMR). It acts by suppressing reactive oxygen species (ROS) and NADPH oxidase, thereby weakening the interaction between ROS and TRPV1. This product is suitable for research concerning respiratory-related diseases.
- Orally active inhibitor of the TRPV1 receptor.
- Selectively inhibits laryngeal chemoreflex (LCR).
- Inhibits LCR by suppressing reactive oxygen species (ROS) and NADPH oxidase.
- Can be used in research of respiratory-related diseases.
- Solid, white to light yellow in appearance.
- Purity of 99.96%.
- For research use only.
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Medchemexpress LLC T56-LIMKi | 924473-59-6 | 98.7% | 389.33 | 100 MG
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T56-LIMKi is a selective inhibitor of LIMK2 that efficiently inhibits the growth of various cancer cell lines including Panc-1, ST88-14, U87, and A549 lung cancer cells. It operates by decreasing phosphorylated cofilin levels, thereby inhibiting tumor cell migration, growth, and anchorage-independent colony formation.
- Selective inhibitor of LIMK2
- Inhibits the growth of various cancer cell lines
- Decreases phosphorylated cofilin levels
- Blocks cofilin phosphorylation, leading to actin severance
- Reduces tumor cell migration and growth
- Induces tumor shrinkage in vivo in mouse models
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Apexbio Technology LLC Erianin 95041-90-0 5mg
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Erianin (CAS 95041-90-0) is a naturally derived small molecule known for its antipyretic and analgesic properties Mechanistically Erianin acts by inhibiting indoleamine 2 3-dioxygenase (IDO)-mediated tumor angiogenesis thereby disrupting the immunoregulatory and pro-angiogenic pathways associated with tumor progression This compound is utilized in biomedical research to investigate mechanisms of tumor immune evasion and vascularization and to explore novel strategies for cancer therapy targeting IDO-driven angiogenic processes
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Medchemexpress LLC 16:0-18:2 PA sodium | 322647-59-6 | MFCD00674300 | 95.0% | 694.89 | 50 MG
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16:0-18:2 PA sodium is a glycerophospholipid that acts as a bioactive lipid and secondary messenger. It is intended for research use only and not for human, veterinary, or therapeutic applications. It is supplied as a solid and can be used as a biological marker to indicate pathological states.
- Regulates various enzyme activities.
- Functions as a bioactive lipid and secondary messenger.
- Associated with hydrogen peroxide production in neutrophils.
- Stimulates protein kinase action for neutrophil respiratory burst.
- Participates in Ras mediated signaling pathways.
- Supplied in powder form.
- Color is white to off-white.
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Medchemexpress LLC Topilutamide | 260980-89-0 | 99.9% | 403.23 | 1 ML
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Topilutamide is a topical nonsteroidal antiandrogen (NSAA) used in the treatment of prostate cancer. First-generation NSAAs are commonly used to treat metastatic prostate cancer. It is a nonsteroidal antiandrogen.
- Topical nonsteroidal antiandrogen
- Used in the treatment of prostate cancer
- Effective in metastatic prostate cancer treatment
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